Pilot Grant: Epigenetic modification of mitochondrial genes in Alzheimer's disease (AD)
Role: PI (Katie Lunnon)
Agency: Alzheimer's Research UK
Amount: £30,000
Dates: 1st June 2013 - 31st May 2015
Psychobiological sequelae of cumulative exposure to violence: The Environmental Risk Longitudinal Twin Study
Role: co-investigator (PI: Louise Arsenault)
Agency: MRC
Amount: £2,738,755
Aims: To follow-up members of the E-Risk cohort at age 18 and assess psychobiological consequences of early-life risk factors.
Dates: 1st July 2011 - 30th June 2016
Epigenetic Pathways to Conduct Problem Trajectories: the Role of Prenatal and Postnatal Environmental Risk Exposures
Role: co-PI (with Ted Barker)
Agency: NIH (NICHD)
Amount: £1,300,000
Aims: Longitudinal epigenetic profiling from birth in samples obtained from the ALSPAC birth cohort
Dates: 1st January 2012 (estimated) - 31st December 2015 (estimated)
Epigenetic and Transcriptional Dysregulation in Autism Spectrum Disorder
Role: co-investigator (PI: Dan Geschwind, UCLA)
Agency: NIH (NIMH)
Amount: $2,500,000
Aims: To undertake an integrated -omics analysis across brain regions in autism
Dates: 25th August 2011 - 30th June 2015
Suicidality: Treatment Occurring In Paediatrics (STOP)
Role: co-investigator (PI: Kathy Aitchison)
Agency: EU
Amount: £71,498
Aims: We are involved in a methodological work=package examining the utility of peripheral sources of biological material for genomic
methodologies
Dates: 1st November 2010 - 30th April 2014
DNA methylation and adolescent depression: an MZ differences study
Role: co-investigator (PI: Thalia Eley)
Agency: Psychiatry Research Trust
Amount: £47,800
Aims: To assess genome-wide patterns of epigenetic differences between monozygotic twins discordant for adolescent depression.
Dates: 1st September 2011 - 31st August 2013
A multifaceted approach to epigenomic dysfunction in Alzheimer’s Disorder
Role: PI
Agency: NIH
Grant Number: 1R01AG036039-01
Amount: $1,779,829 (direct costs)
Aims: As part of the NIH Epigenomics Roadmap Initiative, we plan to map epigenetic changes associated with Alzheimer’s disorder in post-mortem brain tissue, examining the degree to which these are reflected in peripheral blood samples from the same individuals.
Dates: 30th September 2009 - 31st August 2013
Epigenetic mechanisms of memory storage
Role: Co-investigator (PI Ted Abel, University of Pennsylvania)
Agency: NIH
Amount: $118,610 (first year direct costs to KCL)
Grant Number: 1R01MH087463-01A1
Aims: The aim of our subcontract is to profile DNA methylation across key loci in the hippocampus in a rodent model of learning and memory.
Dates: 16th July 2010 - 30th April 2014
De novo epigenetic changes and paternal age in schizophrenia
Role: co-PI (with Dr Avi Reichenberg)
Agency: British Medical Association Research Award
Direct Costs: £40,000
Aims: To examine the hypothesis that epigenetic changes occurring in the sperm of older fathers, subsequently transmitted to their offspring,
explain the increased rate of schizophrenia observed in the offspring of older fathers.
Dates: 1st September 2008 - 31st August 2011
Identical twins discordant for autism: Epigenetic (DNA methylation) biomarkers of non-shared environmental influences
Role: Co-investigator (PI Robert Plomin)
Agency: Autism Speaks
Direct Costs: $300,000
Grant Number: 4743
Aims: To identify epigenetic differences between monozygotic twins discordant for autism.
Dates: 1st April 2009 - 31st March 2012
The role of epigenetic processes in mediating the molecular and behavioural responses to stress in the dentate gyrus
Role: Co-investigator (PI Hans Reul, University of Bristol)
Agency: BBSRC
Direct Costs: £890,436
Grant Number: BB/G02507X/1
Aims: To explore DNA methylation and histone mofication changes in neuronal cells in the dentate gyrus in response to stress
Dates: 1st October 2009 - 30th April 2013
Equipment Grant: Pyrosequencer for DNA methylation analysis
Role: PI
Agency: Alzheimer’s Research Trust
Direct costs: £20,000
Aims: Equipment grant enabling us to add a Pyrosequencer to our lab for methylation analysis
Dates: 1st March 2010 - 28th February 2011